Cetrimonium chlorideby Naturallythinking Safety Data Sheet (SDS)

SDS for Cetrimonium chloride

Safety Data Sheet (SDS) dated 24/05/2024

Batch Number: FRAMECPSR

Section 1: Identification of Product and Supplier

Product Name: Cetrimonium chloride
Product Number: 5060330635599
Brand: Naturallythinking
UK: Naturallythinking, Unit 2 Mill Lane Trading Estate, Mill Lane, Croydon, CR0 4AA
EU: NTEU Ltd (HE 426545), Nikis 1, Anthoupoli, 2350, Nicosia, Cyprus
Contact Telephone: 020 38563588
Contact Email: support@naturallythinking.eu

Section 2: Hazards IDENTIFICATION

2.1 Classification of the substance or mixture


Human Health
Acute. Tox. 3 - H301; Skin. Irrit. 2 - H315; Eye. Dam. 1 - H318; STOT SE 3 - H335

2.2 Label elements According to Regulation (EC) No. 1272/2008 (CLP)

2.2.1 Label elements

GHS Product Identifier: Cetrimonium chloride

Hazard pictogram(s)


Toxic if swallowed
Causes skin irritation
Causes serious eye damage
May cause respiratory irritation
Very toxic to aquatic life




Section 3: Composition and information on Ingredients

Inci: Cetrimonium chloride
Cas: 112-02-7
Einecs: 203-928-6

3.1. Substances

Qty Name
>=30% - <40% Cetyltrimethylammonium chloride
>=70% Aqua

3.2. Mixtures

Product type and use: Quaternary ammonium compound for all hair preparations as
antistatic and conditioning agent.

Hazardous components within the meaning of the CLP regulation and related classification:

Qty Name Ident. Number Classification
>=30% - <40% Cetyltrimethylammonium chloride CAS: 112-02-7
EC: 203-928-6
REACH No.: 01-2119970558-23-XXXX
3.1/3/Dermal Actue Tox. 3 H311
3.2/1C Skin Corr. 1C H314
3.3/1 Eye Dam. 1 H318
4.1/C1 Aquatic Chronic 1 H410 M=1
3.1/4/Oral Acute Tox. 4 H302
4.1/A1 Aquatic Acute 1 H400 M=10


Section 4: First aid measures

4.1. Description of first aid measures
In case of skin contact:
Immediately take off all contaminated clothing.
Remove contaminated clothing immediately and dispose off safely.
After contact with skin, wash immediately with soap and plenty of water.
In case of eyes contact:
After contact with the eyes, rinse with water with the eyelids open for a sufficient length of time,
then consult an opthalmologist immediately.
Protect uninjured eye.
In case of Ingestion:
Do NOT induce vomiting.
In case of Inhalation:
Remove casualty to fresh air and keep warm and at rest.
4.2. Most important symptoms and effects, both acute and delayed
4.3. Indication of any immediate medical attention and special treatment needed
In case of accident or unwellness, seek medical advice immediately (show directions for use or
safety data sheet if possible).

Section 5: Fire - Fighting measures

5.1. Extinguishing media
Suitable extinguishing media:
Carbon dioxide (CO2).
Extinguishing media which must not be used for safety reasons:
None in particular.
5.2. Special hazards arising from the substance or mixture
Do not inhale explosion and combustion gases.
Burning produces heavy smoke.
5.3. Advice for firefighters
Use suitable breathing apparatus .
Collect contaminated fire extinguishing water separately. This must not be discharged into
Move undamaged containers from immediate hazard area if it can be done safely.

Section 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures
Wear personal protection equipment.
Remove persons to safety.
See protective measures under point 7 and 8.
6.2. Environmental precautions
Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains.
Retain contaminated washing water and dispose it.
In case of gas escape or of entry into waterways, soil or drains, inform the responsible
Suitable material for taking up: absorbing material, organic, sand
6.3. Methods and material for containment and cleaning up
Wash with plenty of water.
6.4. Reference to other sections
See also section 8 and 13

Section 7: Handling and Storage

7.1. Precautions for safe handling
Avoid contact with skin and eyes, inhalation of vapours and mists.
Don't use empty container before they have been cleaned.
Before making transfer operations, assure that there aren't any incompatible material residuals
in the containers.
Contamined clothing should be changed before entering eating areas.
Do not eat or drink while working.
See also section 8 for recommended protective equipment.
7.2. Conditions for safe storage, including any incompatibilities
Storage recommended at room temperature
Keep away from food, drink and feed.
Incompatible materials:
None in particular.
Instructions as regards storage premises:
Adequately ventilated premises.
7.3. Specific end use(s)
None in particular

Section 8: Exposure controls and personal protection

8.1. Control parameters
No occupational exposure limit available
DNEL Exposure Limit Values
Cetyltrimethylammonium chloride - CAS: 112-02-7
Worker Professional: 3.32 mg/m3 - Exposure: Human Inhalation - Frequency: Long Term,
systemic effects
Worker Professional: 4.7 mg/kg - Exposure: Human Oral - Frequency: Long Term,
systemic effects
Consumer: 0.98 mg/m3 - Exposure: Human Inhalation - Frequency: Long Term, systemic
Consumer: 2.83 mg/kg - Exposure: Human Dermal - Frequency: Long Term, systemic
Consumer: 2.83 mg/kg - Exposure: Human Oral - Frequency: Long Term, local effects
PNEC Exposure Limit Values
Cetyltrimethylammonium chloride - CAS: 112-02-7
Target: Fresh Water - Value: 0.00068 mg/l
Target: Marine water - Value: 0.000068 mg/l
Target: Freshwater sediments - Value: 9.27 mg/kg
Target: Marine water sediments - Value: 0.927 mg/kg
Target: Soil (agricultural) - Value: 7 mg/kg
8.2. Exposure controls
Eye protection:
Eye protection: Safety glasses with side-shields (frame goggles) (e.g. EN 166)
Protection for skin:
Use clothing that provides comprehensive protection to the skin, e.g. cotton, rubber, PVC or
Protection for hands:
Hand protection:
Chemical resistant protective gloves (EN 374)
Suitable materials also with prolonged, direct contact (Recommended: Protective index 6,
corresponding > 480 minutes of permeation time according to EN 374)
Respiratory protection:
Suitable respiratory protection for higher concentrations or long-term effect: Particle filter with
medium /high
efficiency for solid particles (e.g. EN 143 or 149, Type P2 or FFP2)
Thermal Hazards:
Environmental exposure controls:
Appropriate engineering controls:

Section 9: Physical data and chemical properties

Properties Value Method  
Appearance and Colour Liquid clear, yellowish -- --
Odour Characterisic -- --
Odour Threshold N.A. -- --
pH 6 -- --
Melting point / freezing point 0c -- --
Initial boiling point and boiling range 100c -- --
Flash point >100c -- --
Evaporation rate N.A. -- --
Solid/gas flammability N.A. -- --
Upper/lower flammability or explosive limits N.A. -- --
Vapour pressure ca. 3kPA @ 25c -- --
Vapour density N.A. -- --
Relative density 0.97 g/cm3 -- --
Solubility in water SOLUBLE -- --
Solubility in oil SOLUBLE -- --
Partition coefficient (n-octanol/water) <4 -- --
Auto-ignition temperature N.A. -- --
Decomposition temperature N.A. -- --
Viscosity < 100 mPa.s (20c) -- --
Explosive properties N.A. -- --
Oxidising properties N.A. -- --

9.2. Other information

Properties Value Method  
Miscibility N.A. -- --
Fat soubuility N.A. -- --
Conductivity N.A. -- --
Substance groups relevant properties N.A. -- --


Section 10: Stability & Reactivity

10.1. Reactivity
no hazardous reactions if stored and handled as indicated
10.2. Chemical stability
The product is stable if stored and handles as prescribed/indicate
10.3. Possibility of hazardous reactions
No hazardus reaction when stored and handled as prescribe/indicated
10.4. Conditions to avoid
subtances to avoid: strong oxiding agents, strong bases, strong acids
10.5. Incompatible materials
None in particular.
10.6. Hazardous decomposition products

Section 11: Toxicological Information

11.1. Information on toxicological effects
Toxicological information of the product:
a) acute toxicity
The product is classified: Acute Tox. 4 H312
b) skin corrosion/irritation
The product is classified: Skin Corr. 1C H314
c) serious eye damage/irritation
The product is classified: Eye Dam. 1 H318
d) respiratory or skin sensitisation
Not classified
Based on available data, the classification criteria are not met
e) germ cell mutagenicity
Not classified
Based on available data, the classification criteria are not met
f) carcinogenicity
Not classified
Based on available data, the classification criteria are not met
g) reproductive toxicity
Not classified
Based on available data, the classification criteria are not met
h) STOT-single exposure
Not classified
Based on available data, the classification criteria are not met
i) STOT-repeated exposure
Not classified
Based on available data, the classification criteria are not met
j) aspiration hazard
Not classified
Based on available data, the classification criteria are not met

Toxicological information of the main substances found in the product:
Cetyltrimethylammonium chloride - CAS: 112-02-7
a) acute toxicity:
Test: LD50 - Route: Oral - Species: Rat 1550 mg/kg - Source: OECD 401
Test: LD50 - Route: Skin - Species: Rat 528 mg/kg - Source: OECD 402
b) skin corrosion/irritation:
Test: Skin Irritant - Route: Skin - Species: Rabbit Positive - Source: OECD 404
c) serious eye damage/irritation:
Test: Eye Corrosive - Species: Rabbit Positive - Source: OECD 405
d) respiratory or skin sensitisation:
Test: Skin Sensitization - Route: Skin - Species: Guinea pig Negative - Source: OECD
e) germ cell mutagenicity:
Test: Mutagenesis Negative
f) carcinogenicity:
Test: Carcinogenicity Negative

Section 12: Ecological information

12.1. Toxicity
Adopt good working practices, so that the product is not released into the environment.
The product is classified: Aquatic Acute 1 - H400; Aquatic Chronic 1 - H410
Cetyltrimethylammonium chloride - CAS: 112-02-7
a) Aquatic acute toxicity:
Endpoint: LC50 - Species: Fish 0.7-1 mg/l - Duration h: 96 - Notes: OECD 203
Endpoint: EC50 - Species: Daphnia 0.09 mg/l - Duration h: 48 - Notes: OECD 202
b) Aquatic chronic toxicity:
Endpoint: EC50 - Species: Daphnia 0.0068 mg/l - Notes: 21 days OECD TG 211
c) Bacteria toxicity:
Endpoint: EC50 - Species: Activated Sludge 3.2 ml/l - Notes: DIN 38412 T.8
e) Plant toxicity:
Endpoint: EC50 - Species: Algae 0.08 mg/l - Duration h: 96 - Notes: OECD 201
12.2. Persistence and degradability
Biodegradability: Readily biodegradable - Test: Dissolved organic carbon - Duration: 28
days - %: 75 - Notes: OECD 302B, COD= 170 mg/g
Biodegradability: Readily biodegradable - Test: N.A. - Duration: 28 days - %: 95 - Notes:
oecd 301B
Biodegradability: N.A.Test: Oxygen consumption - Duration: N.A. - %: N.A. - Notes: 650

12.3. Bioaccumulative potential
12.4. Mobility in soil
12.5. Results of PBT and vPvB assessment
vPvB Substances: None - PBT Substances: None
12.6. Other adverse effects

Section 13: Disposal considerations

13.1. Waste treatment methods
Recover, if possible. Send to authorised disposal plants or for incineration under controlled
conditions. In so doing, comply with the local and national regulations currently in force.

Section 14: Transport information

14.1. UN number
ADR-UN Number: 3082
IATA-UN Number: 3082
IMDG-UN Number: 3082

14.2. UN proper shipping name
N.O.S (Cetyltrimethylammonium chloride)
N.O.S (Cetyltrimethylammonium chloride)
N.O.S (Cetyltrimethylammonium chloride)
14.3. Transport hazard class(es)
ADR-Class: 9
ADR - Hazard identification number: 90
IATA-Class: 9
IMDG-Class: 9
14.4. Packing group
ADR-Packing Group: III
IATA-Packing group: III
IMDG-Packing group: III
14.5. Environmental hazards
ADR-Enviromental Pollutant: Yes
IMDG-Marine pollutant: Marine Pollutant
14.6. Special precautions for user
ADR-Transport category (Tunnel restriction code): (E)
14.7. Transport in bulk according to Annex II of Marpol and the IBC Code

Section 15: Regulatory information

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
Dir. 98/24/EC (Risks related to chemical agents at work)
Dir. 2000/39/EC (Occupational exposure limit values)
Regulation (EC) n. 1907/2006 (REACH)
Regulation (EC) n. 1272/2008 (CLP)
Regulation (EC) n. 790/2009 (ATP 1 CLP) and (EU) n. 758/2013
Regulation (EU) 2015/830
Regulation (EU) n. 286/2011 (ATP 2 CLP)
Regulation (EU) n. 618/2012 (ATP 3 CLP)
Regulation (EU) n. 487/2013 (ATP 4 CLP)
Regulation (EU) n. 944/2013 (ATP 5 CLP)
Regulation (EU) n. 605/2014 (ATP 6 CLP)
Regulation (EU) n. 2015/1221 (ATP 7 CLP)
Restrictions related to the product or the substances contained according to Annex XVII Regulation
(EC) 1907/2006 (REACH) and subsequent modifications:
Volatile Organic compounds - VOCs = 0.00 g/l
Volatile CMR substances = 0.00 %
Halogenated VOCs which are assigned the risk phrase R40 = 0.00 %
Organic Carbon - C = 0.00
Where applicable, refer to the following regulatory provisions :
Directive 2012/18/EU (Seveso III)
Regulation (EC) nr 648/2004 (detergents).
Dir. 2004/42/EC (VOC directive)
Provisions related to directive EU 2012/18 (Seveso III):
Seveso III category according to Annex 1, part 1
Product belongs to category: E1
15.2. Chemical safety assessment
No Chemical Safety Assessment has been carried out for the mixture.
Substances for which a Chemical Safety Assessment has been carried out:

Section 16: Other information

Text of phrases referred to under heading 3:
H311 Toxic in contact with skin.
H314 Causes severe skin burns and eye damage.
H318 Causes serious eye damage.
H410 Very toxic to aquatic life with long lasting effects.
H302 Harmful if swallowed.
H400 Very toxic to aquatic life

GMO Declaration

We declare that at present all our regisered and commercially available ingredients, extracts, oils, plants and skincare products are derived by traditional plant breeding methods. We do not have any ingredient, extract, oil or skincare product from genetically modified material

To the best of our knowledge, the information contained in the sheet is correct. However, we cannot accept responsibility for any consequences from its use.

Animal Testing Declaration

UK: As set out under the conditions in Schedule 34 - Amendment of Regulation (EC) No 1223/2009 and related amendments of The Product Safety and Metrology etc. (Amendment etc.) (EU Exit) Regulations 2019 neither the cosmetic nor its component product has been tested on animal purposes

EU:As set out in under the conditions in 1223/2009. Art. 15 Nar. Parliament and the Council of the EU 952/2013 neither the cosmetic nor its component product has been tested on animal purposes


We believe there is already a “safe” and known group of product ingredients used in the cosmetics industry which leave enough scope to be creative and innovative in product formulation without the need for anymore animal testing on new experimental ingredients.

Our suppliers each also agree to not to carry out animal testing on the products and ingredients we purchase. We have a self-imposed cut-off date of 2006 (this was the date our cosmetic formulations came into being) although in reality our suppliers normally have animal testing dates far in excess of this or have never tested at all.

We do not conduct any form of animal testing.

We do not commission any form of animal testing from a third party.

We operate a fixed cut-off date for animal testing and ingedients, which means we will not use any ingredient that has been tested or retested on animals for cosmetics purposes since January 1, 2006

If we find that a company is involved in animal testing in anyway that purchases from us, then we will cease supply immediately. It is a term and condition that by purchasing from Naturallythinking you will not involve yourself or your company in any form of Animal Testing, any violation of this will be dealt with as per any violation of our terms and condtions